Personalized Medicine for Nervous System Manifestations of von Hippel–Lindau Disease
نویسندگان
چکیده
منابع مشابه
Personalized Medicine for Nervous System Manifestations of von Hippel–Lindau Disease
von Hippel-Lindau disease (VHL) is a familial neoplasia syndrome associated with multisystem tumor development. Depending on tumor type and location, current treatments for VHL-associated tumors can include a combination of chemotherapy, radiation therapy, and/or surgery. Central nervous system (CNS) manifestations of VHL include craniospinal hemangioblastomas and endolymphatic sac tumors (ELST...
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IN 1880 and again in 1882 Henry Eales of Birmingham described the clinical picture of primary recurrent retinal haemorrhage in young adults. His seven cases were all young men, whose ages ranged from 14 to 29. They had in common a history of headache, epistaxis, variations in peripheral circulation, dyspepsia, and chronic constipation. One was diagnosed as having mitral incompetence, and in two...
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Von Hippel-Lindau (VHL) disease is a tumor syndrome that frequently involves the central nervous system (CNS). It is caused by germline mutation of the VHL gene. Subsequent VHL inactivation in selected cells is followed by numerous well-characterized molecular consequences, in particular, activation and stabilization of hypoxia-inducible factors HIF1 and HIF2. The link between VHL gene inactiva...
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ژورنال
عنوان ژورنال: Frontiers in Surgery
سال: 2016
ISSN: 2296-875X
DOI: 10.3389/fsurg.2016.00039